![]() ![]() Unlike better understood autoimmune disorders, like rheumatoid arthritis or lupus, there weren’t any obvious indications of an abnormal immune response in people with narcolepsy. The Autoimmune HypothesisĪs researchers looked for clues to the causes of narcolepsy, the so-called autoimmune hypothesis emerged. ![]() Sensing that the antibodies were a threat, the immune system targeted them and destroyed neurons that produce hypocretin. Similarly, a 2015 study suggests that the vaccine produced antibodies that bound to receptors in the brain responsible for sleep. ![]() Genetic mutations play a role as well.Ī 2017 study notes that environmental factors, like the H1N1 influenza virus (swine flu) and the Pandemrix vaccine used in that 2009 flu outbreak, may trigger an autoimmune response. Stress and physical injury may be risk factors. The reasons why a person develops an autoimmune disorder aren’t always clear.
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